A New Strategy for Treating Demyelinating Diseases

Partial deletion of p75NTR in large-diameter DRG neurons exerts no influence upon the survival of peripheral sensory neurons in vivo

Z Qin, DG Gonsalvez, RJ Wood, F Daemi, S Yoo, JJ Ivanusic, EJ Coulson, SS Murray, J Xiao

2020-10-01

The p75 neurotrophin receptor (p75^NTR) is required for maintaining peripheral sensory neuron survival and function; how..

Imaging and Quantification of Myelin Integrity After Injury With Spectral Confocal Reflectance Microscopy

DG Gonsalvez, SW Yoo, JL Fletcher, RJ Wood, GA Craig, SS Murray, J Xiao

2019-11-19

Developing a high-throughput approach to quantify the extent of myelin integrity in preclinical models of demyelinating diseases w..

TrkB Agonist LM22A-4 Increases Oligodendroglial Populations During Myelin Repair in the Corpus Callosum

HTH Nguyen, RJ Wood, AR Prawdiuk, SGB Furness, J Xiao, SS Murray, JL Fletcher

2019-08-27

The neurotrophin, brain-derived neurotrophic factor (BDNF) promotes central nervous system (CNS) myelination during development an..

Peripheral nerve regeneration is independent from Schwann cell p75NTR expression

NP Gonçalves, S Mohseni, M El Soury, M Ulrichsen, M Richner, J Xiao, RJ Wood, OM Andersen, EJ Coulson, S Raimondo, SS Murray, CB Vægter

2019-05-14

Schwann cell reprogramming and differentiation are crucial prerequisites for neuronal regeneration and re-myelination to occur fol..

Inhibiting bone morphogenetic protein 4 type i receptor signaling promotes remyelination by potentiating oligodendrocyte differentiation

AE Govier-Cole, RJ Wood, JL Fletcher, DG Gonsalvez, D Merlo, HS Cate, SS Murray, J Xiao

2019-01-01

Blocking inhibitory factors within CNS demyelinating lesions is regarded as a promising strategy to promote remyelination. Bone mo..

The dynamics of oligodendrocyte generation: how distinct is the mouse from the human?

David Gonsalvez, Georgina Craig, Darragh Walsh, Barry Hughes, Rhiannon Wood, Sang Won Yoo, Simon Murray, Junhua Xiao

2019-01-01

Murine oligodendrocyte generation dynamics are considered distinct from those in the human, with implications for cross-species di..

Targeting TrkB with a brain-derived neurotrophic factor mimetic promotes myelin repair in the brain

JL Fletcher, RJ Wood, J Nguyen, EML Norman, CMK Jun, AR Prawdiuk, M Biemond, HTH Nguyen, SE Northfield, RA Hughes, DG Gonsalvez, J Xiao, SS Murray

2018-08-08

Methods to promote myelin regeneration in response to central myelin loss are essential to prevent the progression of clinical dis..

BDNF haploinsufficiency exerts a transient and regionally different influence upon oligodendroglial lineage cells during postnatal development

M Nicholson, RJ Wood, JL Fletcher, M van den Buuse, SS Murray, J Xiao

2018-07-01

Brain-Derived Neurotrophic Factor (BDNF) plays important roles in promoting myelination in the developing central nervous system (..

Myelin protein zero180-199 peptide induced experimental autoimmune neuritis in C57BL/6 mice

DG Gonsalvez, SW Yoo, GA Craig, RJ Wood, JL Fletcher, SS Murray, J Xiao

2018-01-01

Mouse models of peripheral demyelinating neuropathy play an important role in enabling the study of disease pathogenesis. Further,..

A brain-derived neurotrophic factor-based p75NTR peptide mimetic ameliorates experimental autoimmune neuritis induced axonal pathology and demyelination

DG Gonsalvez, G Tran, JL Fletcher, RA Hughes, S Hodgkinson, RJ Wood, SW Yoo, M De Silva, WW Agnes, C McLean, P Kennedy, TJ Kilpatrick, SS Murray, J Xiao

2017-06-28

Axonal damage and demyelination are major determinants of disability in patients with peripheral demyelinating neuropathies. The n..

Fyn is an intermediate kinase that BDNF utilizes to promote oligodendrocyte myelination

H Peckham, L Giuffrida, R Wood, D Gonsalvez, A Ferner, TJ Kilpatrick, SS Murray, J Xiao

2016-02-01

Fyn, a member of the Src family of nonreceptor tyrosine kinases, promotes central nervous system myelination during development; h..

TDP6, a brain-derived neurotrophic factor-based trkB peptide mimetic, promotes oligodendrocyte myelination

AW Wong, L Giuffrida, R Wood, H Peckham, D Gonsalvez, SS Murray, RA Hughes, J Xiao

2014-11-01

Brain-derived neurotrophic factor (BDNF) plays critical roles in the development and maintenance of the central (CNS) and peripher..